Over the last couple of months Juanfran Granados from Mirai, an hotelier agency that used WordPress extensively, worked hard to add multisite administration capabilities to Autoptimize:

• If AO has been network-activated, there will be an entry-point in the network settings screens where one can configure Autoptimize for the entire network.
• On the subsites the AO settings screen will show a message that settings are done at a network level
• On the network-AO-settings there is an option to allow AO to be configured per site
• if AO has not been network-activated, things work as they do now; all settings are done on a per-site level

I have just merged his code into separate branch on Github and given that significant changes that went into this (almost all files changed), I need you and you and you and … to download and test that multisite-test branch before I merge the changes into the beta branch. Looking forward to your feedback!